AcT study design summary
AcT study design summary
  • *
    i.e., significantly impacting functioning without qualification of specific deficits.2
  • †
    Single, decile-weight-tiered bolus, maximum 25 mg.
  • ‡
    Number refers to the ITT population in this arm.
  • §
    Using a previously validated minimal sufficient balance algorithm.
  • ¶
    10% bolus immediately followed by 90% as IV infusion over 60 minutes, max 90 mg.

AIS: acute ischaemic stroke; IV: intravenous; mRS: modified Rankin Scale; sICH: symptomatic intracerebral haemorrhage.

  1. Menon BK, et al. Lancet 2022;400:161–169 (including supplementary appendix).
  2. Nair R, et al. Stroke Vasc Neurol 2024:9(6):604–612